中科院上海药物研究所导师介绍：沈竞康

姓名:

沈竞康

性别:

男

职称:

研究员

学历:

博士

电子邮件:

jkshen@mail.shcnc.ac.cn

通讯地址:

上海市浦东新区祖冲之路555号201203

简历：

1951年5月出生。1975年毕业于上海医科大学药学院，毕业后留校工作。1986年获该校理学硕士学位。1989年－1993年在日本新泻药科大学工作，并于1993年获日本京都大学药学部博士学位。1994年到中国科学院上海药物研究所从事博士后研究，1995年起留所工作，历任研究员、学术委员会副主任、副所长等职。

研究方向：

生物活性天然产物的结构修饰

基于优势结构、天然活性物质、骨架跃迁、药物信息学等药物化学新技术的靶向化合物库研究

基于结构生物学、药物结构片段的药物发现、结构优化、构效关系研究

专家类别：

研究员

职务：

中科院上海药物所研究员、博士生导师、研究组长

获奖及荣誉：

曾获上海市科技进步二等奖

代表论著：

Meng,T.;Zou,Y.;Khorev,O.;Jin,Y.;Zhou,H.;Zhang,Y.;Hu,D.;Ma,L.;Wang,X.;Shen,J.SimpleandEfficientCopper(I)-CatalyzedAccesstoThreeVersatileAminocoumarin-BasedScaffoldsusingIsocyanoacetate.AdvSynthCatal2011,918-924.

MengzhuXue,MingyueZheng,BingXiong,*YanlianLi,HualiangJiang,andJingkangShen*Knowledge-BasedScoringFunctionsinDrugDesign.1.DevelopingaTarget-SpecificMethodforKinase-LigandInteractions.J.Chem.Inf.Model.2010,50,1378–1386.

LINGQing,ZHOUYue-yang,CAIZheng-liang,ZHANGYa-hui,XIONGBing,MALan-ping,WANGXin,LIXin,LIJia,SHENJing-kang*.SynthesisandLARinhibitionof7-alkoxyanaloguesofilludalicacid.ActaPharmaceuticaSinica2010,45(11),1385-1397.

BingXiong*,JieWu,DavidLBurk,MengzhuXue,HualiangJiang,JingkangShen*，BSSF:afingerprintbasedultrafastbindingsitesimilaritysearchandfunctionanalysisserver，BMCBioinformatics,2010,11,47-58.

TaoMeng,MinLi,YongliangZhang,GuanghuaFang,YuJing,XinWang,JingkangShen*，IntramolecularCyclizationtoNovelSubstitutedBenzimidazo[1,2-a]quinoxalin-6(5H)-onesSynthesis，J.Comb.Chem.,2010,222-224.

YongliDu,QunyiLi,BingXiong,XinHui,XinWang,YangFeng,TaoMeng,DingyuHu,DatongZhang,MingweiWang*,JingkangShen*,Aromaticβ-amino-ketonederivativesasnovelselectivenon-steroidalprogesteronereceptorantagonists,Bioorg.Med.Chem.,2010,18,4255-4268.

TaoMeng,JueWang,HongliPeng*,GuanghuaFang,MinLia,BingXiong,XinXie*,XinWang,JingkangShen*,DiscoveryofBenzhydrylpiperazineDerivativesasCB1ReceptorInverseAgonistsviaPrivilegedStructureBasedApproach,Eur.J.Med.Chem,2010，45，1133－1139.

Hong-xiaGUO,Dai-huaLIU，YingMA,Jin-fengLIU,YingWANG,Zhi-yanDU,XinWANG,Jing-kangSHEN,Hong-liPENG*，Long-termbaicalinadministrationamelioratesmetabolicdisordersandhepaticsteatosisinratsgivenahigh-fatdiet,ActaPharmacolSin,2009;30,1505–1512.

Bi-boYAN,Meng-zhuXUE,BingXIONG*,KeLIU,Ding-yuHU,Jing-kangSHEN*,ScafBank:APublicComprehensiveScaffoldDatabasetoSupportMolecularHopping,ActaPharmacolSin,2009;30（2）,251-258.

YipingZhu,KunXiao,LanpingMa,BinXiong,YanFu,HaipingYu,WeiWang,XinWang,DingyuHu,HongliPeng,JingyaLi,QiGong,QianChai,aXicanTang,HaiyanZhang*,JiaLi*,andJingkangShen*,Design,SynthesisandBiologicalEvaluationofNovelDualInhibitorsofAcetylcholinesteraseandβ-Secretase,Bioorg.Med.Chem.2009;17,1600-1613.

Yi-pingZHU,KunXIAO,Hai-pingYU,Lan-pingMA,BingXIONG,HaiyanZHANG,XinWANG,Jing-yaLI,JiaLI*,Jing-kangSHEN*,Discoveryofpotentβ-secretase(bace-1)inhibitorsbythesynthesisofisophthalamide-containinghybrids,ActaPharmacolSin,2009;30(2),250-270.

BingXiong,KeLiu,JieWu,DavidL.Burk,AlbertM.Berghuis,HualiangJiang,JingkangShen*,DrugViz:aCytoscapeplug-inforvisualizingandanalyzingsmallmoleculedrugsinnetworks,Bioinformatics,2008,24,2117-2118.

QingLing,YueHuang,YueyangZhou,ZhengliangCai,BingXiong,YahuiZhang,LanpingMa,XinWang,XinLi,JiaLi,*andJingkangShen*,IlludalicAcidasaPotentialLARInhibitor:Synthesis,SARandPreliminaryStudiesontheMechanismofAction,Bioorg.Med.Chem.2008,16,7399-7409.

ZhangLiu,YueHuang,WeiZhang,LanpingMa,JingyaLi,XinWang,JiaLi*,andJingkangShen*,SolublePolymer-SupportedSynthesisof5-ArylideneThiazolidinonesandPyrimidinonesUsingaNovelTracelessLinkerStrategy,J.Comb.Chem.,2008,10,632-636.

TaoMENG,Hao-ranSU,ChristophBINKERT,WalterFISCHLI,LingZHOU,Jing-kangSHEN*,Ming-weiWANG*,Identificationofnon-peptidicneuromedinUreceptormodulatorsbyarobusthomogeneousscreeningassay,ActaPharmacolSin,2008;29(4)517-527.

BingXiong,DavidL.BurkJianhuaShen,XiaominLuo,HongLiu,JingkangShen*,AlbertM.Berghuis*,ThetypeIAtopoisomerasecatalyticcycle-Anormalmodeanalysisandmoleculardynamicssimulation,Proteins:Structure,Function,andBioinformatics,2008,1984-1994.

TaoMeng,ZhixiangZhang,DingyuHu,LipingLin,JianDing,XinWang,andJingkangShen*，Three-ComponentCombinatorialSynthesisofaSubstituted6H-Pyrido[2',1':2,3]imidazo-[4,5-c]isoquinolin-5(6H)-oneLibrarywithCytotoxicActivity，J.Comb.Chem.,2007，9(5),739-741.

Hui-XinWan,CaihongZhou,YueyunZhang,MeilingSun,XinWang,HongYu,XiaokeYang,RichardD.Ye,Jing-KangShen*,andMing-WeiWang*,DiscoveryofTrp-Nle-Tyr-Metasanovelagonistforhumanformylpeptidereceptor-like1,Biochem.Pharmacol.2007;74(2),317–326.

LiZhang,BeiyingQiu,BingXiong,XinLi,JingyaLi,XinWang,JiaLi,*andJingkangShen,*QuinoxalinylureaderivativesasanovelclassofJSP-1inhibitors,Bioorg.Med.Chem.Lett.2007;17，2118-2122.

LiZhang,BeiyingQiu,XinLi,XinWang,JingyaLi,YongliangZhang,JianLiu,JiaLi,andJingkangShen,*Preparationof6-SubstitutedQuinoxalineJSP-1InhibitorsbyMicrowaveAcceleratedNucleophilicSubstitution.Molecules2006,11,988-999.

DerongDing,XinLi*,XinWang,YongliDu,JingkangShen*.Microwave-assistedrapidandstraightforwardsynthesisof2-aryl-4-quinolonesfromacylated2'aminoacetophenones,TetrahedronLett.2006;47(39)6997-6999.

BinHU,BingXIONG,Bei-YingQIU,XinLI,Hai-PingYU,XinWANG,JiaLI,Jing-kangSHEN*.Combinatorialchemistryandcomputationalstudyontheinteractionofβ-secretaseanditstemplateinhibitorOM99-2,ActaPharmacologicalSinic.2006，27（12）:1586-1593.

BinHU,KunXIAO,JingkangSHEN*.AMildandefficientsynthesisofchiralN-Boc-α-aminoaldehydes,ChineseChem.Lett.2006，17(9),1162-1164.

Xiao,K.;Li,X.;Li,J-Y.;Ma,L-P.;Hu,B.;Yu,H-P.;Fu,Y.;Wang,R.;Ma,Z-Q.;Qiu,B-Y.;Li,J.;Hu,D-Y.;Wang,X.;Shen,J-K*.Design,synthesis,andevaluationofLeu*Alahydroxyethylene-basednon-peptideb-secretase(BACE)inhibitors,Bioorg.Med.Chem.2006,14,4535-4551.